8SDG

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.43

8SDG の概要

• エントリーDOI: 10.2210/pdb8sdg/pdb
• 分子名称: Neutralizing antibody CC25.43 heavy chain, Neutralizing antibody CC25.43 light chain, Spike protein S1, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, coronavirus, antibody, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 141625.26

構造登録者

Yuan, M.,Wilson, I.A. (登録日: 2023-04-06, 公開日: 2024-03-13, 最終更新日: 2025-07-16)

• 主引用文献: Song, G.,Yuan, M.,Liu, H.,Capozzola, T.,Lin, R.N.,Torres, J.L.,He, W.T.,Musharrafieh, R.,Dueker, K.,Zhou, P.,Callaghan, S.,Mishra, N.,Yong, P.,Anzanello, F.,Avillion, G.,Vo, A.L.,Li, X.,Zhang, Y.,Makhdoomi, M.,Feng, Z.,Zhu, X.,Peng, L.,Nemazee, D.,Safonova, Y.,Briney, B.,Ward, A.B.,Burton, D.R.,Wilson, I.A.,Andrabi, R.; Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift; Cell Rep, 44:115948-, 2025; DOI: 10.1016/j.celrep.2025.115948

実験手法

X-RAY DIFFRACTION (2.71 Å)