8SCD

Crystal structure of sulfonamide resistance enzyme Sul3 in complex with reaction intermediate

8SCD の概要

• エントリーDOI: 10.2210/pdb8scd/pdb
• 関連するPDBエントリー: 7S2I 7S2J 7S2K 7S2L 7S2M 7TQ1
• 分子名称: Sulfonamide resistance enzyme Sul3, 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-AMINOBENZOIC ACID, ... (8 entities in total)
• 機能のキーワード: tim barrel, alpha beta protein, antibiotic resistance, sulfonamides, structural genomics, csgid, center for structural genomics of infectious diseases, csbid, center for structural biology of infectious diseases, niaid, national institute of allergy and infectious diseases, transferase
• 由来する生物種: uncultured bacterium
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29751.38

構造登録者

Stogios, P.J.,Venkatesan, M.,Michalska, K.,Mesa, N.,Di Leo, R.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID),Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2023-04-05, 公開日: 2023-05-03, 最終更新日: 2024-05-22)

• 主引用文献: Venkatesan, M.,Fruci, M.,Verellen, L.A.,Skarina, T.,Mesa, N.,Flick, R.,Pham, C.,Mahadevan, R.,Stogios, P.J.,Savchenko, A.; Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.; Nat Commun, 14:4031-4031, 2023; PubMed: 37419898; DOI: 10.1038/s41467-023-39778-7

実験手法

X-RAY DIFFRACTION (2.06 Å)