8S93

Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase

8S93 の概要

• エントリーDOI: 10.2210/pdb8s93/pdb
• 関連するPDBエントリー: 8GMB 8S9F
• 分子名称: Tyrosine-protein kinase BTK, 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, ZINC ION, ... (5 entities in total)
• 機能のキーワード: bruton's tyrosine kinase, non-receptor tyrosine kinase, complex, lipid-binding, atp-binding, transferase
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53143.01

構造登録者

Lin, D.Y.,Andreotti, A.H. (登録日: 2023-03-27, 公開日: 2023-08-16, 最終更新日: 2024-01-31)

• 主引用文献: Lin, D.Y.,Kueffer, L.E.,Juneja, P.,Wales, T.E.,Engen, J.R.,Andreotti, A.H.; Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.; Elife, 12:-, 2024; PubMed: 38189455; DOI: 10.7554/eLife.89489

実験手法

X-RAY DIFFRACTION (2.1 Å)