8S93
Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE517-VAL529 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | ZN_FING: Btk-type => ECO:0000255|PROSITE-ProRule:PRU00432 |
| Chain | Residue | Details |
| A | ASN135-ARG171 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| Chain | Residue | Details |
| A | ASP521 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q06187 |
| Chain | Residue | Details |
| A | LYS26 | |
| A | ARG28 | |
| A | TYR39 | |
| A | LYS53 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00432 |
| Chain | Residue | Details |
| A | HIS143 | |
| A | CYS154 | |
| A | CYS155 | |
| A | CYS165 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU408 | |
| A | ARG430 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q06187 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q06187 |
| Chain | Residue | Details |
| A | SER21 | |
| A | SER55 | |
| A | SER115 | |
| A | SER604 | |
| A | SER623 | |
| A | SER659 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:17947660 |
| Chain | Residue | Details |
| A | TYR40 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8629002, ECO:0007744|PubMed:17947660 |
| Chain | Residue | Details |
| A | TYR551 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q06187 |
| Chain | Residue | Details |
| A | PRO617 |
