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8S7C

Ternary Complex of Cachd1, FZD5 and LRP6

Summary for 8S7C
Entry DOI10.2210/pdb8s7c/pdb
DescriptorVWFA and cache domain-containing protein 1, Frizzled-5, Low-density lipoprotein receptor-related protein 6, ... (5 entities in total)
Functional Keywordscachd1 frizzled-5 lrp6, signaling protein
Biological sourceMus musculus (house mouse)
More
Total number of polymer chains9
Total formula weight637942.28
Authors
Zhao, Y.,Ren, J.,Jones, E.Y. (deposition date: 2024-02-29, release date: 2024-04-24, Last modification date: 2024-10-16)
Primary citationPowell, G.T.,Faro, A.,Zhao, Y.,Stickney, H.,Novellasdemunt, L.,Henriques, P.,Gestri, G.,Redhouse White, E.,Ren, J.,Lu, W.,Young, R.M.,Hawkins, T.A.,Cavodeassi, F.,Schwarz, Q.,Dreosti, E.,Raible, D.W.,Li, V.S.W.,Wright, G.J.,Jones, E.Y.,Wilson, S.W.
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.
Science, 384:573-579, 2024
Cited by
PubMed Abstract: Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is poorly understood. Genetic screening in zebrafish revealed that loss of function of the transmembrane protein Cachd1 resulted in right-sided habenula neurons adopting left-sided identity. Cachd1 is expressed in neuronal progenitors, functions downstream of asymmetric environmental signals, and influences timing of the normally asymmetric patterns of neurogenesis. Biochemical and structural analyses demonstrated that Cachd1 can bind simultaneously to Lrp6 and Frizzled family Wnt co-receptors. Consistent with this, mutant zebrafish lose asymmetry in the habenulae, and epistasis experiments support a role for Cachd1 in modulating Wnt pathway activity in the brain. These studies identify Cachd1 as a conserved Wnt receptor-interacting protein that regulates lateralized neuronal identity in the zebrafish brain.
PubMed: 38696577
DOI: 10.1126/science.ade6970
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (4.7 Å)
Structure validation

227344

数据于2024-11-13公开中

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