8S7C

Ternary Complex of Cachd1, FZD5 and LRP6

8S7C の概要

• エントリーDOI: 10.2210/pdb8s7c/pdb
• 分子名称: VWFA and cache domain-containing protein 1, Frizzled-5, Low-density lipoprotein receptor-related protein 6, ... (5 entities in total)
• 機能のキーワード: cachd1 frizzled-5 lrp6, signaling protein
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 637942.28

構造登録者

Zhao, Y.,Ren, J.,Jones, E.Y. (登録日: 2024-02-29, 公開日: 2024-04-24, 最終更新日: 2024-10-16)

主引用文献

Powell, G.T.,Faro, A.,Zhao, Y.,Stickney, H.,Novellasdemunt, L.,Henriques, P.,Gestri, G.,Redhouse White, E.,Ren, J.,Lu, W.,Young, R.M.,Hawkins, T.A.,Cavodeassi, F.,Schwarz, Q.,Dreosti, E.,Raible, D.W.,Li, V.S.W.,Wright, G.J.,Jones, E.Y.,Wilson, S.W.
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.
Science, 384:573-579, 2024

PubMed Abstract: Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is poorly understood. Genetic screening in zebrafish revealed that loss of function of the transmembrane protein Cachd1 resulted in right-sided habenula neurons adopting left-sided identity. Cachd1 is expressed in neuronal progenitors, functions downstream of asymmetric environmental signals, and influences timing of the normally asymmetric patterns of neurogenesis. Biochemical and structural analyses demonstrated that Cachd1 can bind simultaneously to Lrp6 and Frizzled family Wnt co-receptors. Consistent with this, mutant zebrafish lose asymmetry in the habenulae, and epistasis experiments support a role for Cachd1 in modulating Wnt pathway activity in the brain. These studies identify Cachd1 as a conserved Wnt receptor-interacting protein that regulates lateralized neuronal identity in the zebrafish brain.

PubMed: 38696577
DOI: 10.1126/science.ade6970

実験手法

X-RAY DIFFRACTION (4.7 Å)