8S50

Cryo-EM structure of the C terminal region of PTX3 with a section of coiled-coil

Summary for 8S50

• Entry DOI: 10.2210/pdb8s50/pdb
• Related: 7ZL1 8PVQ
• EMDB information: 19717
• Descriptor: Pentraxin-related protein PTX3, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: ptx3, pentraxin, pattern, recognition, coiled-coil, coil, innate, immunity, extracellular, octamer, pentraxin-related, cryo-em, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 323418.79

Authors

Snee, M.,Shah, A.,Lockhart-Cairns, M.,Collins, R.,Levy, C.,Baldock, C.,Day, A. (deposition date: 2024-02-22, release date: 2025-01-22)

• Primary citation: Shah, A.,Zhang, X.,Snee, M.,Lockhart-Cairns, M.P.,Levy, C.W.,Jowitt, T.A.,Birchenough, H.L.,Dean, L.,Collins, R.,Dodd, R.J.,Roberts, A.R.,Enghild, J.J.,Mantovani, A.,Fontana, J.,Baldock, C.,Inforzato, A.,Richter, R.P.,Day, A.J.; The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-alpha-inhibitor regulate crosslinking of the hyaluronan matrix; Matrix Biol., 2025; DOI: 10.1016/j.matbio.2025.01.002

Experimental method

ELECTRON MICROSCOPY (3.33 Å)