8S50

Cryo-EM structure of the C terminal region of PTX3 with a section of coiled-coil

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001550	biological_process	ovarian cumulus expansion
A	0001849	molecular_function	complement component C1q complex binding
A	0001872	molecular_function	(1->3)-beta-D-glucan binding
A	0001878	biological_process	response to yeast
A	0002376	biological_process	immune system process
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0008228	biological_process	opsonization
A	0030198	biological_process	extracellular matrix organization
A	0031012	cellular_component	extracellular matrix
A	0035580	cellular_component	specific granule lumen
A	0042802	molecular_function	identical protein binding
A	0044793	biological_process	host-mediated suppression of viral proces
A	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
A	0045087	biological_process	innate immune response
A	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
A	0046597	biological_process	host-mediated suppression of symbiont invasion
A	0046790	molecular_function	virion binding
A	0050766	biological_process	positive regulation of phagocytosis
A	0051707	biological_process	response to other organism
A	1903019	biological_process	negative regulation of glycoprotein metabolic process
A	1904724	cellular_component	tertiary granule lumen
B	0001550	biological_process	ovarian cumulus expansion
B	0001849	molecular_function	complement component C1q complex binding
B	0001872	molecular_function	(1->3)-beta-D-glucan binding
B	0001878	biological_process	response to yeast
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0008228	biological_process	opsonization
B	0030198	biological_process	extracellular matrix organization
B	0031012	cellular_component	extracellular matrix
B	0035580	cellular_component	specific granule lumen
B	0042802	molecular_function	identical protein binding
B	0044793	biological_process	host-mediated suppression of viral proces
B	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
B	0045087	biological_process	innate immune response
B	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
B	0046597	biological_process	host-mediated suppression of symbiont invasion
B	0046790	molecular_function	virion binding
B	0050766	biological_process	positive regulation of phagocytosis
B	0051707	biological_process	response to other organism
B	1903019	biological_process	negative regulation of glycoprotein metabolic process
B	1904724	cellular_component	tertiary granule lumen
C	0001550	biological_process	ovarian cumulus expansion
C	0001849	molecular_function	complement component C1q complex binding
C	0001872	molecular_function	(1->3)-beta-D-glucan binding
C	0001878	biological_process	response to yeast
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0008228	biological_process	opsonization
C	0030198	biological_process	extracellular matrix organization
C	0031012	cellular_component	extracellular matrix
C	0035580	cellular_component	specific granule lumen
C	0042802	molecular_function	identical protein binding
C	0044793	biological_process	host-mediated suppression of viral proces
C	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
C	0045087	biological_process	innate immune response
C	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
C	0046597	biological_process	host-mediated suppression of symbiont invasion
C	0046790	molecular_function	virion binding
C	0050766	biological_process	positive regulation of phagocytosis
C	0051707	biological_process	response to other organism
C	1903019	biological_process	negative regulation of glycoprotein metabolic process
C	1904724	cellular_component	tertiary granule lumen
D	0001550	biological_process	ovarian cumulus expansion
D	0001849	molecular_function	complement component C1q complex binding
D	0001872	molecular_function	(1->3)-beta-D-glucan binding
D	0001878	biological_process	response to yeast
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0008228	biological_process	opsonization
D	0030198	biological_process	extracellular matrix organization
D	0031012	cellular_component	extracellular matrix
D	0035580	cellular_component	specific granule lumen
D	0042802	molecular_function	identical protein binding
D	0044793	biological_process	host-mediated suppression of viral proces
D	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
D	0045087	biological_process	innate immune response
D	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
D	0046597	biological_process	host-mediated suppression of symbiont invasion
D	0046790	molecular_function	virion binding
D	0050766	biological_process	positive regulation of phagocytosis
D	0051707	biological_process	response to other organism
D	1903019	biological_process	negative regulation of glycoprotein metabolic process
D	1904724	cellular_component	tertiary granule lumen
F	0001550	biological_process	ovarian cumulus expansion
F	0001849	molecular_function	complement component C1q complex binding
F	0001872	molecular_function	(1->3)-beta-D-glucan binding
F	0001878	biological_process	response to yeast
F	0002376	biological_process	immune system process
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006954	biological_process	inflammatory response
F	0006955	biological_process	immune response
F	0008228	biological_process	opsonization
F	0030198	biological_process	extracellular matrix organization
F	0031012	cellular_component	extracellular matrix
F	0035580	cellular_component	specific granule lumen
F	0042802	molecular_function	identical protein binding
F	0044793	biological_process	host-mediated suppression of viral proces
F	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
F	0045087	biological_process	innate immune response
F	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
F	0046597	biological_process	host-mediated suppression of symbiont invasion
F	0046790	molecular_function	virion binding
F	0050766	biological_process	positive regulation of phagocytosis
F	0051707	biological_process	response to other organism
F	1903019	biological_process	negative regulation of glycoprotein metabolic process
F	1904724	cellular_component	tertiary granule lumen
G	0001550	biological_process	ovarian cumulus expansion
G	0001849	molecular_function	complement component C1q complex binding
G	0001872	molecular_function	(1->3)-beta-D-glucan binding
G	0001878	biological_process	response to yeast
G	0002376	biological_process	immune system process
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006954	biological_process	inflammatory response
G	0006955	biological_process	immune response
G	0008228	biological_process	opsonization
G	0030198	biological_process	extracellular matrix organization
G	0031012	cellular_component	extracellular matrix
G	0035580	cellular_component	specific granule lumen
G	0042802	molecular_function	identical protein binding
G	0044793	biological_process	host-mediated suppression of viral proces
G	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
G	0045087	biological_process	innate immune response
G	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
G	0046597	biological_process	host-mediated suppression of symbiont invasion
G	0046790	molecular_function	virion binding
G	0050766	biological_process	positive regulation of phagocytosis
G	0051707	biological_process	response to other organism
G	1903019	biological_process	negative regulation of glycoprotein metabolic process
G	1904724	cellular_component	tertiary granule lumen
J	0001550	biological_process	ovarian cumulus expansion
J	0001849	molecular_function	complement component C1q complex binding
J	0001872	molecular_function	(1->3)-beta-D-glucan binding
J	0001878	biological_process	response to yeast
J	0002376	biological_process	immune system process
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0006954	biological_process	inflammatory response
J	0006955	biological_process	immune response
J	0008228	biological_process	opsonization
J	0030198	biological_process	extracellular matrix organization
J	0031012	cellular_component	extracellular matrix
J	0035580	cellular_component	specific granule lumen
J	0042802	molecular_function	identical protein binding
J	0044793	biological_process	host-mediated suppression of viral proces
J	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
J	0045087	biological_process	innate immune response
J	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
J	0046597	biological_process	host-mediated suppression of symbiont invasion
J	0046790	molecular_function	virion binding
J	0050766	biological_process	positive regulation of phagocytosis
J	0051707	biological_process	response to other organism
J	1903019	biological_process	negative regulation of glycoprotein metabolic process
J	1904724	cellular_component	tertiary granule lumen
K	0001550	biological_process	ovarian cumulus expansion
K	0001849	molecular_function	complement component C1q complex binding
K	0001872	molecular_function	(1->3)-beta-D-glucan binding
K	0001878	biological_process	response to yeast
K	0002376	biological_process	immune system process
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0006954	biological_process	inflammatory response
K	0006955	biological_process	immune response
K	0008228	biological_process	opsonization
K	0030198	biological_process	extracellular matrix organization
K	0031012	cellular_component	extracellular matrix
K	0035580	cellular_component	specific granule lumen
K	0042802	molecular_function	identical protein binding
K	0044793	biological_process	host-mediated suppression of viral proces
K	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
K	0045087	biological_process	innate immune response
K	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
K	0046597	biological_process	host-mediated suppression of symbiont invasion
K	0046790	molecular_function	virion binding
K	0050766	biological_process	positive regulation of phagocytosis
K	0051707	biological_process	response to other organism
K	1903019	biological_process	negative regulation of glycoprotein metabolic process
K	1904724	cellular_component	tertiary granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HlCgTWnS

Chain	Residue	Details
B	HIS269-SER276

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1616
Details	Domain: {"description":"Pentraxin (PTX)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01172","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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