8RX0
(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
Summary for 8RX0
Entry DOI | 10.2210/pdb8rx0/pdb |
EMDB information | 19567 |
Descriptor | Isoform B of Bromodomain-containing protein 4, (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, ZINC ION, ... (11 entities in total) |
Functional Keywords | ubiquitin, cullin, ring, e2 complex, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 9 |
Total formula weight | 197625.30 |
Authors | Crowe, C.,Nakasone, M.A.,Ciulli, A. (deposition date: 2024-02-05, release date: 2024-03-06, Last modification date: 2024-09-04) |
Primary citation | Crowe, C.,Nakasone, M.A.,Ciulli, A. (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub To Be Published, |
Experimental method | ELECTRON MICROSCOPY (3.7 Å) |
Structure validation
Download full validation report