8RX0
(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform B of Bromodomain-containing protein 4 | polymer | 111 | 12978.1 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 2 | B (B) | von Hippel-Lindau disease tumor suppressor | polymer | 160 | 18558.2 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 3 | C (D) | Elongin-C | polymer | 96 | 10843.4 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D (C) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | E (E) | Cullin-2 | polymer | 745 | 87098.9 | 1 | UniProt (Q13617) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (human) | CUL-2 |
| 6 | F (G) | Ubiquitin-conjugating enzyme E2 R1 | polymer | 236 | 26762.7 | 1 | UniProt (P49427) Pfam (PF00179) | Homo sapiens (human) | (E3-independent) E2 ubiquitin-conjugating enzyme R1,E2 ubiquitin-conjugating enzyme R1,Ubiquitin-conjugating enzyme E2-32 kDa complementing,Ubiquitin-conjugating enzyme E2-CDC34,Ubiquitin-protein ligase R1 |
| 7 | G (N) | NEDD8 | polymer | 77 | 8661.1 | 1 | UniProt (Q15843) Pfam (PF00240) | Homo sapiens (human) | Neddylin,Neural precursor cell expressed developmentally down-regulated protein 8,NEDD-8,Ubiquitin-like protein Nedd8 |
| 8 | H (R) | E3 ubiquitin-protein ligase RBX1, N-terminally processed | polymer | 96 | 11196.8 | 1 | UniProt (P62877) Pfam (PF12678) | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,N-terminally processed |
| 9 | I (U) | Polyubiquitin-B | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) Pfam (PF00240) UniProt (by SIFTS) (P0CG48) | Homo sapiens (human) | |
| 10 | J (B) | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 1004.7 | 1 | Chemie (759) | |||
| 11 | K, L, M (R) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
N: 1 - 76 (UniProt: Q15843)
R: 16 - 108 (UniProt: P62877)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 13 | - | expression tag |
| His 14 | - | expression tag |
| Met 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 196424.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1200.9 | |
| All* | Total formula weight | 197625.3 |
