8RUZ

Anaerobic HIF prolyl-hydroxylase-2 (PHD2) T387S variant bound to acetate (ACT) and Hypoxia-inducible Factor-2alpha (HIF-2alpha)

Summary for 8RUZ

• Entry DOI: 10.2210/pdb8ruz/pdb
• Descriptor: Egl nine homolog 1, Hypoxia-inducible Factor-2alpha, ACETATE ION, ... (4 entities in total)
• Functional Keywords: 2og oxygenase, oxygen sensing, prolyl hydroxylase, substrate complex, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 27690.40

Authors

Fiorini, G.,Schofield, C.J. (deposition date: 2024-01-31, release date: 2025-02-12)

• Primary citation: Fiorini, G.,Schofield, C.J.; Investigating gatekeeper residues in Prolyl hydroxyalse 2; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.82 Å)