8RUU

Fabs derived from bimekizumab in complex with IL-17F

Summary for 8RUU

• Entry DOI: 10.2210/pdb8ruu/pdb
• Descriptor: Immunoblobulin heavy chain, Immunoblobulin light chain, Interleukin-17F, ... (5 entities in total)
• Functional Keywords: complex fab bimekizumab il-17f, il-17a, bkz, immune system, immunosuppressant
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 127275.69

Authors

Adams, R.,Lawson, A.D.G. (deposition date: 2024-01-31, release date: 2024-04-24, Last modification date: 2024-11-06)

• Primary citation: Adams, R.,Bunick, C.G.,Lawson, A.D.G.,Gomez, B.,Shaw, S.; Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition.; J Invest Dermatol., 144:2581-, 2024; PubMed: 38631666; DOI: 10.1016/j.jid.2024.03.037

Experimental method

X-RAY DIFFRACTION (2.81 Å)