8RUU

Fabs derived from bimekizumab in complex with IL-17F

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0001819	biological_process	positive regulation of cytokine production
X	0002225	biological_process	positive regulation of antimicrobial peptide production
X	0002250	biological_process	adaptive immune response
X	0002376	biological_process	immune system process
X	0005125	molecular_function	cytokine activity
X	0005126	molecular_function	cytokine receptor binding
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0005886	cellular_component	plasma membrane
X	0006954	biological_process	inflammatory response
X	0016525	biological_process	negative regulation of angiogenesis
X	0017015	biological_process	regulation of transforming growth factor beta receptor signaling pathway
X	0019955	molecular_function	cytokine binding
X	0032645	biological_process	regulation of granulocyte macrophage colony-stimulating factor production
X	0032663	biological_process	regulation of interleukin-2 production
X	0032675	biological_process	regulation of interleukin-6 production
X	0032677	biological_process	regulation of interleukin-8 production
X	0032755	biological_process	positive regulation of interleukin-6 production
X	0032761	biological_process	positive regulation of lymphotoxin A production
X	0042803	molecular_function	protein homodimerization activity
X	0045087	biological_process	innate immune response
X	0046982	molecular_function	protein heterodimerization activity
X	0050829	biological_process	defense response to Gram-negative bacterium
X	0050830	biological_process	defense response to Gram-positive bacterium
X	0051216	biological_process	cartilage development
X	0070534	biological_process	protein K63-linked ubiquitination
X	0072538	biological_process	T-helper 17 type immune response
X	0080090	biological_process	regulation of primary metabolic process
X	0097400	biological_process	interleukin-17-mediated signaling pathway
X	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
X	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
Y	0001819	biological_process	positive regulation of cytokine production
Y	0002225	biological_process	positive regulation of antimicrobial peptide production
Y	0002250	biological_process	adaptive immune response
Y	0002376	biological_process	immune system process
Y	0005125	molecular_function	cytokine activity
Y	0005126	molecular_function	cytokine receptor binding
Y	0005515	molecular_function	protein binding
Y	0005576	cellular_component	extracellular region
Y	0005615	cellular_component	extracellular space
Y	0005886	cellular_component	plasma membrane
Y	0006954	biological_process	inflammatory response
Y	0016525	biological_process	negative regulation of angiogenesis
Y	0017015	biological_process	regulation of transforming growth factor beta receptor signaling pathway
Y	0019955	molecular_function	cytokine binding
Y	0032645	biological_process	regulation of granulocyte macrophage colony-stimulating factor production
Y	0032663	biological_process	regulation of interleukin-2 production
Y	0032675	biological_process	regulation of interleukin-6 production
Y	0032677	biological_process	regulation of interleukin-8 production
Y	0032755	biological_process	positive regulation of interleukin-6 production
Y	0032761	biological_process	positive regulation of lymphotoxin A production
Y	0042803	molecular_function	protein homodimerization activity
Y	0045087	biological_process	innate immune response
Y	0046982	molecular_function	protein heterodimerization activity
Y	0050829	biological_process	defense response to Gram-negative bacterium
Y	0050830	biological_process	defense response to Gram-positive bacterium
Y	0051216	biological_process	cartilage development
Y	0070534	biological_process	protein K63-linked ubiquitination
Y	0072538	biological_process	T-helper 17 type immune response
Y	0080090	biological_process	regulation of primary metabolic process
Y	0097400	biological_process	interleukin-17-mediated signaling pathway
Y	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
Y	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR206-HIS212
C	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19838198","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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