8RU8
A crystal form of a human CDK2-CDK7 chimera
Summary for 8RU8
Entry DOI | 10.2210/pdb8ru8/pdb |
Descriptor | Cyclin-dependent kinase 2, (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol (3 entities in total) |
Functional Keywords | cyclin dependent kinase 7, serine/threonine kinase, atp binding, cell cycle kinase, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35166.86 |
Authors | Mukherjee, M.,Cleasby, A. (deposition date: 2024-01-30, release date: 2024-06-26, Last modification date: 2024-08-21) |
Primary citation | Mukherjee, M.,Day, P.J.,Laverty, D.,Bueren-Calabuig, J.A.,Woodhead, A.J.,Griffiths-Jones, C.,Hiscock, S.,East, C.,Boyd, S.,O'Reilly, M. Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 32:1040-1048.e3, 2024 Cited by PubMed: 38870939DOI: 10.1016/j.str.2024.05.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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