8RSM

Crystal structure of Streptococcus pyogenes macrodomain in complex with ADP-ribose

Summary for 8RSM

Entry DOI	10.2210/pdb8rsm/pdb
Descriptor	Protein-ADP-ribose hydrolase, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (4 entities in total)
Functional Keywords	adp-ribosylation, adp-ribose, adp-ribosylhydrolase, lipoylation, metalloenzyme, hydrolase
Biological source	Streptococcus pyogenes
Total number of polymer chains	1
Total formula weight	31049.46
Authors	Ariza, A. (deposition date: 2024-01-24, release date: 2024-09-25, Last modification date: 2024-10-02)
Primary citation	Ariza, A.,Liu, Q.,Cowieson, N.,Ahel, I.,Filippov, D.V.,Rack, J.G.M. Evolutionary and molecular basis of ADP-ribosylation reversal by zinc-dependent macrodomains. J.Biol.Chem., :107770-107770, 2024 Cited by PubMed: 39270823 DOI: 10.1016/j.jbc.2024.107770 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation