8RRQ
Crystal structure of human SYK in complex with compound 24
This is a non-PDB format compatible entry.
Summary for 8RRQ
Entry DOI | 10.2210/pdb8rrq/pdb |
Descriptor | Tyrosine-protein kinase SYK, N-[(1S,2R)-2-azanylcyclohexyl]-5-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-2-methyl-pyrazole-3-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | inhibitor, kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33379.28 |
Authors | |
Primary citation | Cervi, G.,D'Alessio, R.,Bindi, S.,Buffa, L.,Burocchi, A.,Canevari, G.,Modugno, M.,Motto, I.,Saturno, G.,Orsini, P. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur.J.Med.Chem., 270:116375-116375, 2024 Cited by PubMed: 38604095DOI: 10.1016/j.ejmech.2024.116375 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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