8RQ9
Crystal structure of PROTAC CFT-1297 in complex with CRBN-midi and BRD4(BD2)
This is a non-PDB format compatible entry.
Summary for 8RQ9
Entry DOI | 10.2210/pdb8rq9/pdb |
Related | 8RQ1 8RQ8 8RQA 8RQC |
Descriptor | Protein cereblon, Bromodomain-containing protein 4, (3~{S})-3-[7-[1-[7-[4-[6-(4-chlorophenyl)-1-methyl-spiro[[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4,1'-cyclopropane]-8-yl]pyrazol-1-yl]heptyl]piperidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]piperidine-2,6-dione, ... (5 entities in total) |
Functional Keywords | e3 ligase, protac, tpd, targeted protein degradation, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 106857.91 |
Authors | Darren, D.,Ramachandran, S.,Kroupova, A.,Zollman, D.,Ciulli, A. (deposition date: 2024-01-17, release date: 2024-09-25) |
Primary citation | Kroupova, A.,Zollman, D.,Ciulli, A. Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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