8RQ9
Crystal structure of PROTAC CFT-1297 in complex with CRBN-midi and BRD4(BD2)
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Protein cereblon | polymer | 329 | 37478.8 | 2 | UniProt (Q96SW2) In PDB | Homo sapiens (human) | |
2 | B, D | Bromodomain-containing protein 4 | polymer | 130 | 15060.3 | 2 | UniProt (O60885) In PDB | Homo sapiens (human) | Protein HUNK1 |
3 | A, C | (3~{S})-3-[7-[1-[7-[4-[6-(4-chlorophenyl)-1-methyl-spiro[[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4,1'-cyclopropane]-8-yl]pyrazol-1-yl]heptyl]piperidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]piperidine-2,6-dione | non-polymer | 824.4 | 2 | Chemie (A1H2F) | |||
4 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, C: 41 - 187 (UniProt: Q96SW2)
A, C: 249 - 426 (UniProt: Q96SW2)
B, D: 333 - 460 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Ser 40 | - | expression tag |
Ile 78 | Cys 78 | engineered mutation |
Val 92 | Ile 92 | engineered mutation |
Asn 116 | Lys 116 | engineered mutation |
Glu 134 | Gln 134 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 188 | - | linker |
Ser 189 | - | linker |
Gly 190 | - | linker |
Trp 283 | Arg 283 | engineered mutation |
Asn 287 | Cys 287 | engineered mutation |
Ser 293 | Val 293 | engineered mutation |
Asp 302 | Gly 302 | engineered mutation |
Arg 342 | Leu 342 | engineered mutation |
Glu 343 | Cys 343 | engineered mutation |
Ile 359 | Thr 359 | engineered mutation |
Ile 423 | Leu 423 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 331 | - | expression tag |
Met 332 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 105078.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1779.6 | |
All* | Total formula weight | 106857.9 |