8RQ8

Crystal structure of CRBN-midi in complex with mezigdomide

Summary for 8RQ8

• Entry DOI: 10.2210/pdb8rq8/pdb
• Related: 8RQ1
• Descriptor: Protein cereblon, ZINC ION, Mezigdomide, ... (4 entities in total)
• Functional Keywords: e3 ligase, protac, tpd, molecular glue, targeted protein degradation, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 38111.82

Authors

Zollman, D.,Kroupova, A.,Pethe, J.,Ciulli, A. (deposition date: 2024-01-17, release date: 2024-09-25)

• Primary citation: Kroupova, A.,Zollman, D.,Ciulli, A.; Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.19 Å)