8RQ9

Crystal structure of PROTAC CFT-1297 in complex with CRBN-midi and BRD4(BD2)

This is a non-PDB format compatible entry.

Summary for 8RQ9

• Entry DOI: 10.2210/pdb8rq9/pdb
• Related: 8RQ1 8RQ8 8RQA 8RQC
• Descriptor: Protein cereblon, Bromodomain-containing protein 4, (3~{S})-3-[7-[1-[7-[4-[6-(4-chlorophenyl)-1-methyl-spiro[[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4,1'-cyclopropane]-8-yl]pyrazol-1-yl]heptyl]piperidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]piperidine-2,6-dione, ... (5 entities in total)
• Functional Keywords: e3 ligase, protac, tpd, targeted protein degradation, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 106857.91

Authors

Darren, D.,Ramachandran, S.,Kroupova, A.,Zollman, D.,Ciulli, A. (deposition date: 2024-01-17, release date: 2024-09-25)

• Primary citation: Kroupova, A.,Zollman, D.,Ciulli, A.; Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.91 Å)