8RO6

Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Apo closed P-loop conformation

Summary for 8RO6

Entry DOI	10.2210/pdb8ro6/pdb
Descriptor	Structural maintenance of chromosomes protein 1A (SMC1A), 64-kDa C-terminal product (3 entities in total)
Functional Keywords	3d genome organization, chromatin, cohesin, atpase activity, atpase cycle, nuclear protein
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	60647.88
Authors	Shaik, T.B.,Romier, C. (deposition date: 2024-01-11, release date: 2024-09-11, Last modification date: 2024-09-18)
Primary citation	Vitoria Gomes, M.,Landwerlin, P.,Diebold-Durand, M.L.,Shaik, T.B.,Durand, A.,Troesch, E.,Weber, C.,Brillet, K.,Lemee, M.V.,Decroos, C.,Dulac, L.,Antony, P.,Watrin, E.,Ennifar, E.,Golzio, C.,Romier, C. The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains. Cell Rep, 43:114656-114656, 2024 Cited by PubMed: 39240714 DOI: 10.1016/j.celrep.2024.114656 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation