8RO6

Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Apo closed P-loop conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0007062	biological_process	sister chromatid cohesion
A	0008278	cellular_component	cohesin complex
A	0016887	molecular_function	ATP hydrolysis activity
B	0007062	biological_process	sister chromatid cohesion
B	0008278	cellular_component	cohesin complex

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKTVAALALLF

Chain	Residue	Details
A	LEU1128-PHE1142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by ATM => ECO:0000269|PubMed:11877377, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLN960

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ARG965

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by ATM and ATR => ECO:0000269|PubMed:11877377, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:22977523, ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	ILE969

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	ARG973

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CU62

Chain	Residue	Details
A	LYS1037

---