8RDX

PGGtase I in complex with probe BAY-6092

This is a non-PDB format compatible entry.

Summary for 8RDX

• Entry DOI: 10.2210/pdb8rdx/pdb
• Descriptor: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Geranylgeranyl transferase type-1 subunit beta, ZINC ION, ... (7 entities in total)
• Functional Keywords: inhibitor, transferase
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 12
• Total formula weight: 466929.53

Authors

Steuber, H. (deposition date: 2023-12-08, release date: 2024-02-14, Last modification date: 2024-04-10)

• Primary citation: Graham, K.,Lienau, P.,Bader, B.,Prechtl, S.,Naujoks, J.,Lesche, R.,Weiske, J.,Kuehnlenz, J.,Brzezinka, K.,Potze, L.,Zanconato, F.,Nicke, B.,Montebaur, A.,Bone, W.,Golfier, S.,Kaulfuss, S.,Kopitz, C.,Pilari, S.,Steuber, H.,Hayat, S.,Kamburov, A.,Steffen, A.,Schlicker, A.,Buchgraber, P.,Braeuer, N.,Font, N.A.,Heinrich, T.,Kuhnke, L.,Nowak-Reppel, K.,Stresemann, C.,Steigemann, P.,Walter, A.O.,Blotta, S.,Ocker, M.,Lakner, A.,von Nussbaum, F.,Mumberg, D.,Eis, K.,Piccolo, S.,Lange, M.; Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.; Cell Chem Biol, 2024; PubMed: 38537632; DOI: 10.1016/j.chembiol.2024.02.013

Experimental method

X-RAY DIFFRACTION (3.67 Å)