Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RDX

PGGtase I in complex with probe BAY-6092

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008318	molecular_function	protein prenyltransferase activity
A	0018342	biological_process	protein prenylation
B	0003824	molecular_function	catalytic activity
B	0004661	molecular_function	protein geranylgeranyltransferase activity
B	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
B	0005515	molecular_function	protein binding
B	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
B	0008270	molecular_function	zinc ion binding
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008318	molecular_function	protein prenyltransferase activity
B	0018344	biological_process	protein geranylgeranylation
B	0036094	molecular_function	small molecule binding
B	0042277	molecular_function	peptide binding
B	0045787	biological_process	positive regulation of cell cycle
B	0080120	biological_process	CAAX-box protein maturation
B	1901363	molecular_function	heterocyclic compound binding
C	0008318	molecular_function	protein prenyltransferase activity
C	0018342	biological_process	protein prenylation
D	0003824	molecular_function	catalytic activity
D	0004661	molecular_function	protein geranylgeranyltransferase activity
D	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
D	0005515	molecular_function	protein binding
D	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
D	0008270	molecular_function	zinc ion binding
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008318	molecular_function	protein prenyltransferase activity
D	0018344	biological_process	protein geranylgeranylation
D	0036094	molecular_function	small molecule binding
D	0042277	molecular_function	peptide binding
D	0045787	biological_process	positive regulation of cell cycle
D	0080120	biological_process	CAAX-box protein maturation
D	1901363	molecular_function	heterocyclic compound binding
E	0008318	molecular_function	protein prenyltransferase activity
E	0018342	biological_process	protein prenylation
F	0003824	molecular_function	catalytic activity
F	0004661	molecular_function	protein geranylgeranyltransferase activity
F	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
F	0005515	molecular_function	protein binding
F	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
F	0008270	molecular_function	zinc ion binding
F	0008284	biological_process	positive regulation of cell population proliferation
F	0008318	molecular_function	protein prenyltransferase activity
F	0018344	biological_process	protein geranylgeranylation
F	0036094	molecular_function	small molecule binding
F	0042277	molecular_function	peptide binding
F	0045787	biological_process	positive regulation of cell cycle
F	0080120	biological_process	CAAX-box protein maturation
F	1901363	molecular_function	heterocyclic compound binding
G	0008318	molecular_function	protein prenyltransferase activity
G	0018342	biological_process	protein prenylation
H	0003824	molecular_function	catalytic activity
H	0004661	molecular_function	protein geranylgeranyltransferase activity
H	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
H	0005515	molecular_function	protein binding
H	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
H	0008270	molecular_function	zinc ion binding
H	0008284	biological_process	positive regulation of cell population proliferation
H	0008318	molecular_function	protein prenyltransferase activity
H	0018344	biological_process	protein geranylgeranylation
H	0036094	molecular_function	small molecule binding
H	0042277	molecular_function	peptide binding
H	0045787	biological_process	positive regulation of cell cycle
H	0080120	biological_process	CAAX-box protein maturation
H	1901363	molecular_function	heterocyclic compound binding
I	0008318	molecular_function	protein prenyltransferase activity
I	0018342	biological_process	protein prenylation
J	0003824	molecular_function	catalytic activity
J	0004661	molecular_function	protein geranylgeranyltransferase activity
J	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
J	0005515	molecular_function	protein binding
J	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
J	0008270	molecular_function	zinc ion binding
J	0008284	biological_process	positive regulation of cell population proliferation
J	0008318	molecular_function	protein prenyltransferase activity
J	0018344	biological_process	protein geranylgeranylation
J	0036094	molecular_function	small molecule binding
J	0042277	molecular_function	peptide binding
J	0045787	biological_process	positive regulation of cell cycle
J	0080120	biological_process	CAAX-box protein maturation
J	1901363	molecular_function	heterocyclic compound binding
K	0008318	molecular_function	protein prenyltransferase activity
K	0018342	biological_process	protein prenylation
L	0003824	molecular_function	catalytic activity
L	0004661	molecular_function	protein geranylgeranyltransferase activity
L	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
L	0005515	molecular_function	protein binding
L	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
L	0008270	molecular_function	zinc ion binding
L	0008284	biological_process	positive regulation of cell population proliferation
L	0008318	molecular_function	protein prenyltransferase activity
L	0018344	biological_process	protein geranylgeranylation
L	0036094	molecular_function	small molecule binding
L	0042277	molecular_function	peptide binding
L	0045787	biological_process	positive regulation of cell cycle
L	0080120	biological_process	CAAX-box protein maturation
L	1901363	molecular_function	heterocyclic compound binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Repeat: {"description":"PFTA 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	204
Details	Repeat: {"description":"PFTA 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	192
Details	Repeat: {"description":"PFTA 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	204
Details	Repeat: {"description":"PFTA 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	204
Details	Repeat: {"description":"PFTA 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	252
Details	Repeat: {"description":"PFTB 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	246
Details	Repeat: {"description":"PFTB 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	234
Details	Repeat: {"description":"PFTB 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	252
Details	Repeat: {"description":"PFTB 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N4P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
A	LYS164	electrostatic stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
C	LYS164	electrostatic stabiliser

site_id	MCSA3
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
E	LYS164	electrostatic stabiliser

site_id	MCSA4
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
G	LYS164	electrostatic stabiliser

site_id	MCSA5
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
I	LYS164	electrostatic stabiliser

site_id	MCSA6
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
K	LYS164	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)