8RCW
Crystal structure of the Mycobacterium tuberculosis regulator VirS (N-terminal fragment 4-208) in complex with the lead compound SMARt751
Summary for 8RCW
| Entry DOI | 10.2210/pdb8rcw/pdb |
| Descriptor | HTH-type transcriptional regulator VirS, 4,4,4-tris(fluoranyl)-1-[4-(4-fluorophenyl)piperidin-1-yl]butan-1-one (3 entities in total) |
| Functional Keywords | arac family, transcription, tuberculosis, dna binding protein, in situ proteolysis |
| Biological source | Mycobacterium tuberculosis H37Rv |
| Total number of polymer chains | 2 |
| Total formula weight | 51242.45 |
| Authors | Grosse, C.,Sigoillot, M.,Megalizzi, V.,Tanina, A.,Willand, N.,Baulard, A.R.,Wintjens, R. (deposition date: 2023-12-07, release date: 2024-04-10) |
| Primary citation | Grosse, C.,Sigoillot, M.,Megalizzi, V.,Tanina, A.,Willand, N.,Baulard, A.R.,Wintjens, R. Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751. J.Struct.Biol., 216:108090-108090, 2024 Cited by PubMed: 38548139DOI: 10.1016/j.jsb.2024.108090 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.692 Å) |
Structure validation
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