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8RBC

p53-Y220C Core Domain Covalently Bound to 3-amino-5-chloropyrazine-2,6-dicarbonitrile Soaked at 5 mM

Summary for 8RBC
Entry DOI10.2210/pdb8rbc/pdb
Related8RBA 8RBB
DescriptorCellular tumor antigen p53, 3-azanylpyrazine-2,6-dicarbonitrile, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
Functional Keywordscovalent, snar, stabilization, cell cycle
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight50448.84
Authors
Stahlecker, J.,Klett, T.,Stehle, T.,Boeckler, F.M. (deposition date: 2023-12-04, release date: 2024-11-27)
Primary citationKlett, T.,Stahlecker, J.,Jaag, S.,Masberg, B.,Knappe, C.,Lammerhofer, M.,Coles, M.,Stehle, T.,Boeckler, F.M.
Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution
Acs Pharmacol Transl Sci, 2024
Cited by
DOI: 10.1021/acsptsci.4c00414
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.06 Å)
Structure validation

229183

PDB entries from 2024-12-18

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