8RBC
p53-Y220C Core Domain Covalently Bound to 3-amino-5-chloropyrazine-2,6-dicarbonitrile Soaked at 5 mM
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 380 |
Details | DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
Chain | Residue | Details |
A | THR102-LYS292 | |
B | THR102-LYS292 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 |
Chain | Residue | Details |
A | CYS176 | |
A | HIS179 | |
A | CYS238 | |
A | CYS242 | |
B | CYS176 | |
B | HIS179 | |
B | CYS238 | |
B | CYS242 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
Chain | Residue | Details |
A | LYS120 | |
B | LYS120 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: N6-lactoyllysine => ECO:0000269|PubMed:38653238 |
Chain | Residue | Details |
A | LYS120 | |
A | LYS139 | |
B | LYS120 | |
B | LYS139 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 |
Chain | Residue | Details |
A | SER183 | |
A | SER269 | |
B | SER183 | |
B | SER269 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 |
Chain | Residue | Details |
A | THR284 | |
B | THR284 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314 |
Chain | Residue | Details |
A | LYS305 | |
B | LYS305 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 |
Chain | Residue | Details |
A | LYS291 | |
A | LYS292 | |
B | LYS291 | |
B | LYS292 |