8R9A

A soakable crystal form of human CDK7 in complex with AMP-PNP

Summary for 8R9A

Entry DOI	10.2210/pdb8r9a/pdb
Descriptor	Cyclin-dependent kinase 7, DI(HYDROXYETHYL)ETHER, (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, ... (4 entities in total)
Functional Keywords	serine-threonine kinase, phosphorylation, cell cycle progression, atp binding, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42736.27
Authors	Mukherjee, M.,Cleasby, A. (deposition date: 2023-11-30, release date: 2024-05-29, Last modification date: 2024-06-26)
Primary citation	Mukherjee, M.,Day, P.J.,Laverty, D.,Bueren-Calabuig, J.A.,Woodhead, A.J.,Griffiths-Jones, C.,Hiscock, S.,East, C.,Boyd, S.,O'Reilly, M. Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 2024 Cited by PubMed: 38870939 DOI: 10.1016/j.str.2024.05.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation