8R8D

Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)

Summary for 8R8D

• Entry DOI: 10.2210/pdb8r8d/pdb
• EMDB information: 18999
• Descriptor: Coagulation factor XII, Garadacimab heavy chain variable region, Garadacimab light chain variable region, ... (5 entities in total)
• Functional Keywords: complex, coagulation, trypsin-like serine protease, hereditary angioedema (hae), blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 150954.34

Authors

Drulyte, I. (deposition date: 2023-11-29, release date: 2023-12-13)

• Primary citation: Drulyte, I.,Ghai, R.,Ow, S.Y.,Kapp, E.A.,Quek, A.J.,Panousis, C.,Wilson, M.J.,Nash, A.D.,Pelzing, M.; Structural basis for inhibition of beta-FXIIa by garadacimab; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)