8R5V

Crystal structure of bovine pancreatic ribonuclease A in complex with [Sp-PS]-mU-dT dinucleotide

Summary for 8R5V

Entry DOI	10.2210/pdb8r5v/pdb
Descriptor	Ribonuclease pancreatic, 1-[(2~{R},4~{S},5~{R})-5-[[[(2~{R},6~{S})-2-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-6-(hydroxymethyl)morpholin-4-yl]-oxidanyl-phosphinothioyl]oxymethyl]-4-oxidanyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione, DICHLORO-ACETIC ACID, ... (4 entities in total)
Functional Keywords	complex, dinucleotide, inhibitor, ribonuclease, rnase, hydrolase
Biological source	Bos taurus (cattle)
Total number of polymer chains	2
Total formula weight	33767.15
Authors	Dolot, R.,Jastrzebska, K.,Antonczyk, P. (deposition date: 2023-11-17, release date: 2023-12-06, Last modification date: 2024-11-20)
Primary citation	Jastrzebska, K.,Antonczyk, P.,Dolot, R. P-Stereodefined morpholino dinucleoside 3',5'-phosphorothioates. Org.Biomol.Chem., 22:8737-8742, 2024 Cited by PubMed Abstract: Here, we present for the first time the synthesis of P-stereodefined morpholino phosphorothioate analogs by using a modified 1,3,2-oxathiaphospholane method (OTP method) and provide valuable structural insights into their stereochemistry. -(2-Thio-4,4-pentamethylene-1,3,2-oxathiaphospholane) derivatives of morpholino-type nucleosides (U-OTPs) were synthesized, separated into pure P-diastereomers and used to prepare P-stereodefined morpholino dinucleoside 3',5'-phosphorothioates. PubMed: 39392463 DOI: 10.1039/d4ob01437e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation