8R5V
Crystal structure of bovine pancreatic ribonuclease A in complex with [Sp-PS]-mU-dT dinucleotide
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF |
| Chain | Residue | Details |
| A | CYS66-PHE72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS38 | |
| B | HIS38 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS145 | |
| B | HIS145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS33 | |
| B | ARG111 | |
| A | ARG36 | |
| A | LYS67 | |
| A | LYS92 | |
| A | ARG111 | |
| B | LYS33 | |
| B | ARG36 | |
| B | LYS67 | |
| B | LYS92 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 |
| Chain | Residue | Details |
| A | LYS27 | |
| A | LYS33 | |
| A | LYS63 | |
| A | LYS67 | |
| B | LYS27 | |
| B | LYS33 | |
| B | LYS63 | |
| B | LYS67 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553 |
| Chain | Residue | Details |
| A | ASN60 | |
| B | ASN60 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 164 |
| Chain | Residue | Details |
| A | HIS38 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS67 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS145 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | PHE146 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP147 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 164 |
| Chain | Residue | Details |
| B | HIS38 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | LYS67 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS145 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | PHE146 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP147 | electrostatic stabiliser, hydrogen bond acceptor |
