8R5R

Structure of apo TDO with a bound inhibitor

Summary for 8R5R

• Entry DOI: 10.2210/pdb8r5r/pdb
• Related: 8qv7
• Descriptor: Tryptophan 2,3-dioxygenase, 3-chloranyl-~{N}-[(1~{S})-1-(6-chloranylpyridin-3-yl)-2-phenyl-ethyl]aniline, alpha-methyl-L-tryptophan, ... (4 entities in total)
• Functional Keywords: inhibitor, apo, heme, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 173758.12

Authors

Wicki, M.,Mac Sweeney, A. (deposition date: 2023-11-17, release date: 2024-01-17)

• Primary citation: Lotz-Jenne, C.,Lange, R.,Cren, S.,Bourquin, G.,Goglia, L.,Kimmerlin, T.,Wicki, M.,Mueller, M.,Artico, N.,Ackerknecht, S.,Joesch, C.,Mac Sweeney, A.; Discovery and binding mode of a small molecule inhibitor of the apo form of human TDO2; Biorxiv, 2024; DOI: 10.1101/2024.01.09.574827

Experimental method

X-RAY DIFFRACTION (3.078 Å)