8R5R

Structure of apo TDO with a bound inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Tryptophan 2,3-dioxygenase	polymer	358	42878.0	4	UniProt (P48775) Pfam (PF03301) In PDB	Homo sapiens (human)
2	A, B, C, D	3-chloranyl-~{N}-[(1~{S})-1-(6-chloranylpyridin-3-yl)-2-phenyl-ethyl]aniline	non-polymer		343.3	4	Chemie (Y5N)
3	A, B, C, D	alpha-methyl-L-tryptophan	non-polymer		218.3	4	Chemie (ZIQ)
4		water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, B, C, D: 39 - 389 (UniProt: P48775)

PDB	External Database	Details
Glu 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	171512.1
Non-Polymers*	Number of molecules	8
	Total formula weight	2246.0
All*	Total formula weight	173758.1

*Water molecules are not included.