8QZD

Soluble epoxide hydrolase in complex with Epoxykinin

Summary for 8QZD

Entry DOI	10.2210/pdb8qzd/pdb
Descriptor	Bifunctional epoxide hydrolase 2, 1,2-ETHANEDIOL, 2-[5-bromanyl-3-[2,2,2-tris(fluoranyl)ethanoyl]indol-1-yl]-N-cycloheptyl-ethanamide, ... (5 entities in total)
Functional Keywords	complex, structural genomics, structural genomics consortium, sgc, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	43221.08
Authors	Kumar, A.,Ehrler, J.M.H.,Ziegler, S.,Doetsch, L.,Proschak, E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-10-27, release date: 2024-02-28, Last modification date: 2024-04-03)
Primary citation	Dotsch, L.,Davies, C.,Hennes, E.,Schonfeld, J.,Kumar, A.,Guita, C.D.C.L.,Ehrler, J.H.M.,Hiesinger, K.,Thavam, S.,Janning, P.,Sievers, S.,Knapp, S.,Proschak, E.,Ziegler, S.,Waldmann, H. Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. J.Med.Chem., 67:4691-4706, 2024 Cited by PubMed: 38470246 DOI: 10.1021/acs.jmedchem.3c02245 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation