8QWN

Structure of p53 cancer mutant Y220C (hexagonal crystal form)

8QWN の概要

• エントリーDOI: 10.2210/pdb8qwn/pdb
• 分子名称: Cellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: tumor suppressor, transcription factor, cancer mutation, protein stability, conformational mutant, dna binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24780.11

構造登録者

Balourdas, D.I.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (登録日: 2023-10-19, 公開日: 2024-06-19)

• 主引用文献: Balourdas, D.I.,Markl, A.M.,Kramer, A.,Settanni, G.,Joerger, A.C.; Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.; Cell Death Dis, 15:408-408, 2024; PubMed: 38862470; DOI: 10.1038/s41419-024-06739-x

実験手法

X-RAY DIFFRACTION (1.44 Å)