8QTK

Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 31)

Summary for 8QTK

Entry DOI	10.2210/pdb8qtk/pdb
Descriptor	E3 ubiquitin-protein ligase CBL-B, ZINC ION, SODIUM ION, ... (5 entities in total)
Functional Keywords	e3 ubiquitin ligase, allosteric inhibitor, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	46459.85
Authors	Schimpl, M. (deposition date: 2023-10-12, release date: 2024-01-24, Last modification date: 2024-02-07)
Primary citation	Mfuh, A.M.,Boerth, J.A.,Bommakanti, G.,Chan, C.,Chinn, A.J.,Code, E.,Fricke, P.J.,Giblin, K.A.,Gohlke, A.,Hansel, C.,Hariparsad, N.,Hughes, S.J.,Jin, M.,Kantae, V.,Kavanagh, S.L.,Lamb, M.L.,Lane, J.,Moore, R.,Puri, T.,Quinn, T.R.,Reddy, I.,Robb, G.R.,Robbins, K.J.,Gancedo Rodrigo, M.,Schimpl, M.,Singh, B.,Singh, M.,Tang, H.,Thomson, C.,Walsh, J.J.,Ware, J.,Watson, I.D.G.,Ye, M.W.,Wrigley, G.L.,Zhang, A.X.,Zhang, Y.,Grimster, N.P. Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. J.Med.Chem., 67:1500-1512, 2024 Cited by PubMed: 38227216 DOI: 10.1021/acs.jmedchem.3c02083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.873 Å)

Structure validation