8QTK
Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 31)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | E3 ubiquitin-protein ligase CBL-B | polymer | 394 | 45809.5 | 1 | UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097) In PDB | Homo sapiens (human) | |
2 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
4 | A | 3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-1-[(1S)-1-(1-methylpyrazol-4-yl)ethyl]-5-(trifluoromethyl)pyridin-2-one | non-polymer | 496.5 | 1 | Chemie (WX9) | |||
5 | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 36 - 427 (UniProt: Q13191)
PDB | External Database | Details |
---|---|---|
His 34 | - | expression tag |
Met 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45809.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 650.3 | |
All* | Total formula weight | 46459.8 |