8QQY

Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with JG165

8QQY の概要

• エントリーDOI: 10.2210/pdb8qqy/pdb
• 分子名称: Ephrin type-A receptor 2, 6-(4-fluoranyl-3-methoxy-phenyl)-13$l^{6}-thia-2,4,8,12,19-pentazatricyclo[12.3.1.1^{3,7}]nonadeca-1(18),3,5,7(19),14,16-hexaene 13,13-dioxide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: epha2, ephrin type-a receptor 2, inhibitor, macrocycle, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35699.19

構造登録者

Zhubi, R.,Gerninghaus, J.,Knapp, S.,Kraemer, A.,Structural Genomics Consortium (SGC) (登録日: 2023-10-06, 公開日: 2023-11-22, 最終更新日: 2024-07-31)

• 主引用文献: Kramer, A.,Tjaden, A.,Ndreshkjana, B.,Tredup, C.,Farin, H.F.,Knapp, S.,Janin, Y.L.,Muller, S.; IPP/CNRS-A017: A chemical probe for human dihydroorotate dehydrogenase (hDHODH); Curr Res Chem Biol, 2:100034-, 2022; DOI: 10.1016/j.crchbi.2022.100034

実験手法

X-RAY DIFFRACTION (1.8 Å)