8QQI
E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800
Summary for 8QQI
Entry DOI | 10.2210/pdb8qqi/pdb |
EMDB information | 18592 |
Descriptor | DNA gyrase subunit A, DNA gyrase subunit B, Mu217 chain E, ... (6 entities in total) |
Functional Keywords | topoisomerase, gyrase, allosteric inhibitor, antibiotic, dna binding protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 6 |
Total formula weight | 313843.23 |
Authors | Ghilarov, D.,Martin, N.I.,van der Stelt, M. (deposition date: 2023-10-04, release date: 2024-06-19, Last modification date: 2024-09-18) |
Primary citation | Bakker, A.T.,Kotsogianni, I.,Avalos, M.,Punt, J.M.,Liu, B.,Piermarini, D.,Gagestein, B.,Slingerland, C.J.,Zhang, L.,Willemse, J.J.,Ghimire, L.B.,van den Berg, R.J.H.B.N.,Janssen, A.P.A.,Ottenhoff, T.H.M.,van Boeckel, C.A.A.,van Wezel, G.P.,Ghilarov, D.,Martin, N.I.,van der Stelt, M. Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria. Nat.Chem., 16:1462-1472, 2024 Cited by PubMed: 38898213DOI: 10.1038/s41557-024-01516-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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