8QQ6

CRYSTAL STRUCTURE OF FVIIA IN COMPLEX WITH A BENZAMIDINE-BASED INHIBITOR

Summary for 8QQ6

Entry DOI	10.2210/pdb8qq6/pdb
Related	8QOD
Descriptor	Factor VII light chain, Coagulation factor VII, Tissue factor, ... (10 entities in total)
Functional Keywords	inhibitor complex, blood clotting
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	72657.68
Authors	Schreuder, H.A.,Liesum, A. (deposition date: 2023-10-03, release date: 2024-10-16)
Primary citation	Tesmer, L.,Hans Matter, H.,Klingler, O.,Schudok, M.,Hessler, G.,Mehdipour, A.R.,Guessregen, S.,Hummer, G.,Schreuder, H.A. Crystallography and molecular simulations capture S1 pocket collapse in allosteric regulation of factor VIIa and other serine proteases. to be published,
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation