8QQ6
CRYSTAL STRUCTURE OF FVIIA IN COMPLEX WITH A BENZAMIDINE-BASED INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Factor VII light chain | polymer | 141 | 16303.8 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | |
| 2 | B (B) | Coagulation factor VII | polymer | 254 | 28103.3 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (human) | Proconvertin,Serum prothrombin conversion accelerator,SPCA |
| 3 | C (C) | Tissue factor | polymer | 243 | 27297.5 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | TF,Coagulation factor III,Thromboplastin |
| 4 | D, H (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 7 | G (A) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
| 8 | I, K (B, C) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 9 | J (B) | 2-azanyl-~{N}-[[2-[2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl]phenyl]methyl]-~{N}-methyl-ethanamide | non-polymer | 433.5 | 1 | Chemie (WSV) | |||
| 10 | L, M, N (A, B, C) | water | water | 18.0 | 704 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 71704.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 953.1 | |
| All* | Total formula weight | 72657.7 |
