8QOO

Crystal structure of human Sirt2 in complex with the peptide-based pseudo-inhibitor TNFn-4.1

Summary for 8QOO

• Entry DOI: 10.2210/pdb8qoo/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, Peptide-based pseudo-inhibitor TNFn-4.1, ZINC ION, ... (8 entities in total)
• Functional Keywords: pseudo-inhibitor, sirtuin 2, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 36246.48

Authors

Friedrich, F.,Kalbas, D.,Meleshin, M.,Einsle, O.,Schutkowski, M.,Jung, M. (deposition date: 2023-09-29, release date: 2024-10-09)

• Primary citation: Friedrich, F.,Kalbas, D.,Einsle, O.,Jung, M.,Schutkowski, M.; Development of potent TNFa-Myr-based pseudo-inhibitors for Sirtuin 2; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)