8QOO
Crystal structure of human Sirt2 in complex with the peptide-based pseudo-inhibitor TNFn-4.1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 304 | 34416.7 | 1 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | B (B) | Peptide-based pseudo-inhibitor TNFn-4.1 | polymer | 10 | 1007.1 | 1 | Homo sapiens | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU3) | |||
| 5 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | F (B) | (2S,3S)-3-dodecylsulfanyl-2-methyl-butanoic acid | non-polymer | 302.5 | 1 | Chemie (WH8) | |||
| 7 | G (B) | (2S,3R)-3-dodecylsulfanyl-2-methyl-butanoic acid | non-polymer | 302.5 | 1 | Chemie (WGN) | |||
| 8 | H, I (A, B) | water | water | 18.0 | 292 | Chemie (HOH) |
Sequence modifications
A: 56 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 53 | - | expression tag |
| His 54 | - | expression tag |
| Met 55 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35423.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 822.6 | |
| All* | Total formula weight | 36246.5 |
