8QMB
Nucleant-assisted 2.0 A resolution structure of the Streptococcus pneumoniae topoisomerase IV-V18mer DNA complex with the novel fluoroquinolone Delafloxacin
Summary for 8QMB
Entry DOI | 10.2210/pdb8qmb/pdb |
Related | 8C41 |
Descriptor | DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A, ACETATE ION, FORMIC ACID, ... (13 entities in total) |
Functional Keywords | protein-dna cleavage complex, topoisomerase iia, delafloxacin, topoisomerase iv-dna-antibiotic complex, isomerase, pegylated graphene |
Biological source | Streptococcus pneumoniae More |
Total number of polymer chains | 6 |
Total formula weight | 181444.30 |
Authors | Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2023-09-21, release date: 2024-10-02) |
Primary citation | Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R. The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin. To Be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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