8QMB
Nucleant-assisted 2.0 A resolution structure of the Streptococcus pneumoniae topoisomerase IV-V18mer DNA complex with the novel fluoroquinolone Delafloxacin
Functional Information from PROSITE/UniProt
site_id | PS00177 |
Number of Residues | 9 |
Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
Chain | Residue | Details |
A | LEU431-GLY439 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:20596531 |
Chain | Residue | Details |
A | GLU433 | |
A | ASP506 | |
A | ASP508 | |
B | GLU433 | |
B | ASP506 | |
B | ASP508 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_00939 |
Chain | Residue | Details |
A | LYS458 | |
A | ASN461 | |
A | HIS513 | |
A | ARG629 | |
B | LYS458 | |
B | ASN461 | |
B | HIS513 | |
B | ARG629 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_00937, ECO:0000269|PubMed:20596531 |
Chain | Residue | Details |
A | TYR1118 | |
B | TYR1118 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | SITE: Interaction with DNA |
Chain | Residue | Details |
A | LYS1038 | |
B | LYS1093 | |
A | HIS1074 | |
A | HIS1076 | |
A | ARG1087 | |
A | LYS1093 | |
B | LYS1038 | |
B | HIS1074 | |
B | HIS1076 | |
B | ARG1087 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
A | ARG1117 | |
B | ARG1117 |