8QHM
DNA mimic Foldamer with sticky ends
Summary for 8QHM
| Entry DOI | 10.2210/pdb8qhm/pdb |
| Descriptor | DNA mimic Foldamer (1 entity in total) |
| Functional Keywords | dna mimic, unknown function |
| Biological source | synthetic construct |
| Total number of polymer chains | 2 |
| Total formula weight | 9230.31 |
| Authors | Deepak, D.,Loos, M.,Huc, I. (deposition date: 2023-09-08, release date: 2023-10-11, Last modification date: 2024-09-04) |
| Primary citation | Corvaglia, V.,Wu, J.,Deepak, D.,Loos, M.,Huc, I. Enhancing the Features of DNA Mimic Foldamers for Structural Investigations. Chemistry, 30:e202303650-e202303650, 2024 Cited by PubMed Abstract: DNA mimic foldamers based on aromatic oligoamide helices bearing anionic phosphonate side chains have been shown to bind to DNA-binding proteins sometimes orders of magnitude better than DNA itself. Here, we introduce new features in the DNA mimic foldamers to facilitate structural investigations of their interactions with proteins. Thirteen new foldamer sequences have been synthesized and characterized using NMR, circular dichroism, molecular modeling, and X-ray crystallography. The results show that foldamer helix handedness can be quantitatively biased by means of a single stereogenic center, that the foldamer structure can be made C-symmetrical as in palindromic B-DNA sequences, and that associations between foldamer helices can be promoted utilizing dedicated C-terminal residues that act as sticky ends in B-DNA structures. PubMed: 38193643DOI: 10.1002/chem.202303650 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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