8QHL

Human Angiotensin-1 converting enzyme N-domain in complex with the lactotripeptide VPP

Summary for 8QHL

• Entry DOI: 10.2210/pdb8qhl/pdb
• Descriptor: Angiotensin-converting enzyme, 1,2-ETHANEDIOL, TETRAETHYLENE GLYCOL, ... (16 entities in total)
• Functional Keywords: angiotensin-i converting enzyme, zinc-dependent endopeptidase, di-peptidyl carboxxypeptidase, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 150677.42

Authors

Gregory, K.S.,Cozier, G.E.,Acharya, K.R. (deposition date: 2023-09-08, release date: 2023-11-22, Last modification date: 2024-02-07)

• Primary citation: Gregory, K.S.,Cozier, G.E.,Schwager, S.L.U.,Sturrock, E.D.,Acharya, K.R.; Structural insights into the inhibitory mechanism of angiotensin-I-converting enzyme by the lactotripeptides IPP and VPP.; Febs Lett., 598:242-251, 2024; PubMed: 37904282; DOI: 10.1002/1873-3468.14768

Experimental method

X-RAY DIFFRACTION (1.9 Å)