8QHL
Human Angiotensin-1 converting enzyme N-domain in complex with the lactotripeptide VPP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, A) | Angiotensin-converting enzyme | polymer | 628 | 72493.4 | 2 | UniProt (P12821) Pfam (PF01401) | Homo sapiens (human) | ACE,Dipeptidyl carboxypeptidase I,Kininase II |
| 2 | B, D (D, C) | VAL-PRO-PRO | polymer | 3 | 311.4 | 2 | Bos taurus | ||
| 3 | E, F (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | G (G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | H (H) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | I, J (I, J) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 7 | K, T (B, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 8 | L, U (B, A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 9 | CA, M, P, R, V... (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 6 | Chemie (PEG) | |||
| 10 | N, O (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 11 | Q, Z (B, A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 12 | S (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 13 | W (A) | BICINE | non-polymer | 163.2 | 1 | Chemie (BCN) | |||
| 14 | Y (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 15 | AA, BA (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 2 | Chemie (1PE) | |||
| 16 | DA, EA, FA, GA (B, D, A, C) | water | water | 18.0 | 444 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 628 (UniProt: P12821)
| PDB | External Database | Details |
|---|---|---|
| Gln 9 | Asn 38 | engineered mutation |
| Gln 25 | Asn 54 | engineered mutation |
| Gln 82 | Asn 111 | engineered mutation |
| Gln 117 | Asn 146 | engineered mutation |
| Gln 131 | Asn 160 | engineered mutation |
| Gln 289 | Asn 318 | engineered mutation |
| Arg 545 | Gln 574 | engineered mutation |
| Leu 576 | Pro 605 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 145609.5 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 2902.7 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2165.2 | |
| All* | Total formula weight | 150677.4 |
