8QGY

Cryo-EM structure of C-terminally truncated Apoptosis signal-regulating kinase 1 (ASK1)

Summary for 8QGY

• Entry DOI: 10.2210/pdb8qgy/pdb
• EMDB information: 18396
• Descriptor: Mitogen-activated protein kinase kinase kinase 5 (1 entity in total)
• Functional Keywords: ask1, map3k, mapk signaling, thioredoxin, apoptosis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 203817.25

Authors

Kosek, D.,Honzejkova, K.,Obsilova, V.,Obsil, T. (deposition date: 2023-09-06, release date: 2024-04-03)

• Primary citation: Honzejkova, K.,Kosek, D.,Obsilova, V.,Obsil, T.; The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1.; Elife, 13:-, 2024; PubMed: 38536085; DOI: 10.7554/eLife.95199

Experimental method

ELECTRON MICROSCOPY (3.71 Å)