8QF2

Beta-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining Beta-L-arabinofuranosidases

This is a non-PDB format compatible entry.

Summary for 8QF2

• Entry DOI: 10.2210/pdb8qf2/pdb
• Descriptor: Non-reducing end beta-L-arabinofuranosidase, ZINC ION, (1~{S},2~{S},3~{S},4~{R})-4-azanyl-3-(hydroxymethyl)cyclopentane-1,2-diol, ... (4 entities in total)
• Functional Keywords: arabinofuranosidase, activity-based probe, cyclophellitol aziridine, hydrolase
• Biological source: Bifidobacterium longum
• Total number of polymer chains: 1
• Total formula weight: 74670.49

Authors

Borlandelli, V.,Offen, W.A.,Moroz, O.,Nin-Hill, A.,McGregor, N.,Binkhorst, L.,Armstrong, Z.,Ishiwata, A.,Artola, M.,Rovira, C.,Davies, G.J.,Overkleeft, H. (deposition date: 2023-09-02, release date: 2023-12-13, Last modification date: 2023-12-27)

• Primary citation: Borlandelli, V.,Offen, W.,Moroz, O.,Nin-Hill, A.,McGregor, N.,Binkhorst, L.,Ishiwata, A.,Armstrong, Z.,Artola, M.,Rovira, C.,Davies, G.J.,Overkleeft, H.S.; beta-l- Arabino furano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining beta-l-Arabinofuranosidases.; Acs Chem.Biol., 18:2564-2573, 2023; PubMed: 38051515; DOI: 10.1021/acschembio.3c00558

Experimental method

X-RAY DIFFRACTION (2.35 Å)